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She co-ordinates her supplementation with Vitamin D blood testing, so that she stays between 40 and 60 ng/ml, generally hovering around 50 ng/ml. I mention this section because for some people Visbiome is hard to get hold of, and up until now, it was thought VSL #3 was a satisfactory alternative. Whilst vitamin K1 is prioritized for use in the liver, vitamin K2 appears to be prioritized for use in the periphery, which will support calcium transport59The relationship between vitamin K and peripheral arterial disease Vissers et al. Dr. Rhonda Patrick has a gift for translating complex scientific topics into actionable insights in her videos, podcasts, and articles. Below summarizes the details: VSL #3 was originally created by Professor Claudio De Simone, and produced by VSL Inc. All the clinical studies before 2016 were performed on the original formula of VSL#3. Rhonda mentioned in her Feb 2021 Q&A she takes melatonin by Pure Encapsulations possibly Pure Encapsulations Melatonin 3mg. OmegaQuant was founded by Bill Harris who Rhonda interviewed recently. What does Rhonda supplement with? It contains 550mg of choline per 2 capsule serving. Micronutrients, a subset of which are referred to as vitamins and minerals, are regarded as essential if experiments show that humans get sick in their absence. For example, probiotics can help regulate the innate and adaptive immune responses by modulating the functions of dendritic cells, macrophages, and T and B lymphocytes81Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases Vanderpool et al. Nootropics are products aimed at improving cognitive function, and in Rhondas June 2021 members Q&A she updated us on her preferred nootropic, which she consumes in the form of a drink. Rhonda mentioned in her February 2023 Q&A that shes continuing to take Life Extension- PQQ 20mg capsules. Rhonda supplements 10 mg of Lutein and 2 mg of Zeaxanthin daily, via a product called Pure Encapsulations Lutein & Zeaxanthin. It comes in 2 different forms, vitamin K1 (phylloquinone) and K2 (menaquinone). The curcumin group had a 28% improvement in their memory/attention abilities and fewer amyloid plaques and tau tangles in the brain, compared to the placebo. In a podcast with Kevin Rose (Jan 2020 link), Rhonda discussed the use of metformin for longevity. She notes that exercise is better at preventing type 2 diabetes than metformin, citing a randomized controlled trial involving 3,200 people90Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin Diabetes Prevention Program Research Group (2002). In addition, the supplement also has 50 mg of quercetin and 100 mg of rutin both flavonoids with potential health benefits. Patrick told Joe Rogan that she supplements with 20 mg of PQQ, citing the antioxidants potential to improve mitochondrial function, increase cognition, and reduce inflammation. She opts for the salmon roe rather than supplements, as its a potent, fresh source of phospholipids (~438 mg of EPA and ~514 mg of DHA per ounce). This amplifies the importance of choosing a supplement that you can rely upon. She is one of Central However, they have since stopped doing IFOS testing for their product (link), so its not possible to check batches for their oxidation levels or heavy metal content. *Oxidation levels come via IFOS batch tests. lds original art; joint mortgage death of spouse. Oddly, the 180 capsule product seems to be called Ester C, and the 90 capsule product; Ester C but they contain the same ingredients. Chromadex also produce Nicotinamide Riboside under their own brand; called Tru Niagen. She bulk buys her caviar from Vital Choice, who offer it in 2.2lbs packages that can be frozen, and then defrosted one quarter at a time. Rhonda Harmon, MD, FACS, is a board-certified general surgeon with AdventHealth Medical Groups specialized surgery team in Orlando. WebSulforaphane, an isothiocyanate compound, is the most potent naturally-occurring inducer of the body's key detoxification enzymes. Her ONE multivitamin already Rhonda currently takes a sulforaphane supplement called BROQ. Dr. Rhonda Patrick retains a Ph.D. in biomedical science and has done her undergraduate studies in biochemistry. For example, as an Amazon Associate, I earn from qualifying purchases. Supplements Mentioned Rhonda supplements with both: High-DHA Norwegian PURE-3 fish oil (3 grams daily) High-EPA Norwegian PURE-3 fish oil Sulforaphane supplements: Avmacol, which contains ~3.5 mg in each tablet (their recommended dose is 2 tablets) This is Kevins sulforaphane supplement of choice he cycles it monthly (1 Its a higher dose per serving (750mg vs 500mg), which is based off clinical studies72Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Studya randomized controlled trial Mastroiacovo et al. In terms of supplementing K2 (menaquinone), there are two key forms; MK4 & MK7. Note: since having her son she has less time for growing broccoli sprouts. Namely: So when it comes to healthy individuals who exercise, she doesnt see any synergy with the use of metformin for improving healthspan and lifespan. iva breaking amish 2020; homes for sale by owner 77083; non toxic tattoo shop near me; instrumentong may mataas na It contains: She says its like dynamite for the brain, and she feels on fire with it . She no longer takes: Rhonda mentioned in her July 2022 Q&A that she takes a total of 2,000 IU per day of vitamin D3 in the Summer and 5,000 IU in the winter. Rhondas multivitamins contain 2,000 IU per day. Its estimated that around 25% of the population have at least 1 ApoE4 allele. Theyre particularly of interest in eye health, because theyre found in the eye lens and macular region of the retina. For Zeaxanthin, according to this paper63Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake James Edwards | 2016 | Journal of Ophthalmology, the EU put an upper use level of 2 mg / day. MK7 has a longer half-life, but MK4 is more studied. Rhondas Dosage: 10 mg Lutein, 2 mg Zeaxanthin. Whereas the Thorne multivitamin contains 140 mcg of Lutein and zero Zeaxanthin. The takeaway is that APOE4s aren't as able to get DHA where it needs to go unless the DHA is in phospholipid form. two syllable italian words; who left channel 7 news boston. For those looking for the benefits of the original VSL# 3 formula, this continues to exist under the Visbiome brand. Saying that if she had to take antibiotics for some reason, then she would take Visbiome probiotics after, in order to replenish the healthy gut bacteria. Dr. Rhonda Patrick on Children Supplementation There are several supplements that Rhonda points out to be crucial in a childs development. For more on David Sinclair and the supplements he takes, including Resveratrol and NMN, see this separate post. WebDr. This can be made by: In terms of which Moringa to use, Jeds studies used Kuli Kuli Moringa (15% off coupon code here). If youve got any queries on the above, please leave them below in the comments. different essential micronutrients we need to consume, in order to stay healthy. In 2018 Rhonda published an open access paper on a possible mechanism for getting DHA into the brain, which bypasses the impaired route. This was in part backed up by a study84P884 No shared mechanisms among old and new VSL#3: Implications for claims and guidelines C De Simone (2018) performed by De Simone, showing that the new VSL#3 formula was materially different to the old one. She describes ubiquinol as playing an important role in mitochondrial energy production. De-prioritizing other functions, such as those that could aid in longevity. Rhonda supplements 10 mg of Lutein and 2 mg of Zeaxanthin daily, via a product called Pure Encapsulations Lutein & Zeaxanthin. The goal of this blog is to share information around health and longevity, with the hope that others find it useful. Vitamin K2 Vitamin K comes in two forms: K1 and K2. ONE contains CoQ10, Alpha lipoic acid, choline, inositol and molybdenum, whilst Thornes does not. Rhonda Patrick's Preferred Sulforaphane Supplements (Avmacol & Prostaphane) & How They Compare to Broccoli Sprouts (4-minute podcast clip) She discusses in this 4-minute podcast clip *This is a site I'm involved in. (2008)82Probiotics: progress toward novel therapies for intestinal diseases Yan et al. Vitamin K2 on the other hand is found in fermented foods, which are less common in a western diet. 7. (2012). This thread is archived Espaol . With extensive experience in marketing, analytics, business operations, finance, and large-scale operations, Patrick founded BodyLogicMD in 2003 As a guideline, below is the list of brands that Rhonda often uses (either currently, or in the past): Then separately, Rhonda has discussed using Labdoor and Consumer Lab in order to check products for contaminants such as heavy metals. I could just strike them from the list, but I think for some this list (and the rationales) may be of interest. Secondly, premium members get a number of exclusive benefits, including members only emails, monthly Ask Me Anything live streams and open access to use her genetics reports. According to Rhonda, omega-3 phospholipids are found in fish, and in greatest concentration in fish roe (fish eggs). Thornes contains much less lutein and. Providing DHA to the brain again, in the form of DHA-lysoPC, may reduce Alzheimers disease risk. See FDA warning and a paper on mycocystins in dietary supplements. See Rhondas research section on metformin for more info. Prior to having her son, Rhonda was experimenting with a Nicotinamide Riboside supplement by Thorne. Shes specifically using Pure Encapsulations Ubiquinol-QH 200mg. Rhonda was previously using a low dose melatonin supplement (300 mcg by Life Extension), based on this research by MIT. This is becausemagnesium composes part of the chlorophyll molecule, the green pigment in plants that helps absorb light. If youre looking for further Rhonda Patrick related content, below are some related posts Ive written: For those curious, see this post for a log of the main updates over time. So, if you see leafy green vegetables, you know youll be able to get some of the bound-up magnesium from it. @foundmyfitness. Visbiome comes in sachet and pill form. For a detailed breakdown of what else this article covers, see the table of contents below: This section covers the supplements Rhonda takes in the morning. A randomized controlled trial showed that a bioavailable form of curcumin improved memory in older people with mild memory complaints. Below is a list of fish oils that have both low oxidation and heavy metal levels, as measured by the IFOS testing. Unfortunately, many people are low in vitamin K1, and therefore may have inadequate levels of K1 to support adequate calcium transport. To enhance her diet with micronutrients and prebiotic fiber, she consumes smoothies daily to increase her raw vegetable intake. Rhondas keen interest in omega-3 phospholipids stems from having 1 ApoE4 allele in her DNA. She has a micronutrient-rich green smoothie every morning Rhonda Harmon is a General Surgeon in Apopka, FL. However, for example with her mother, who doesnt eat as many green vegetables, she encourages a larger supplemental dose. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. In her Dec 2019 Q&A discussion, she discussed Resveratrol, saying that she doesnt take it currently, but is considering taking it. | 2015 | Investigative Ophthalmology & Visual Science. (2014)73Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults Brickman et al. Vitamin C is an essential micronutrient, well known for its antioxidant properties. Interestingly, at price per gram of flavanols, it also works out cheaper than the original version ($2.22/gram vs $3.00/gram). Rhonda wanted to go over her topics and clear up misinformation, but Joe wouldn't let her. The reason for avoiding hot water is because the myrocinase enzyme in moringa is sensitive to heat, and its crucial to preserve it. However, when Di Simone parted ways with VSL Inc. in 2016, manufacturing was switched from USA to Italy and the formulation was changed. Magnesium is a co-factor for over 300 enzymes in the body. Of course, its worth noting that the amount of cocoa in regular chocolate is low so you want to be consuming high cacao content products to receive these benefits. Its a blend of magnesium gluconate, magnesium acetyl taurinate and magnesium citrate, coupled with l-theanine. Rhonda added Moringa powder to her diet after research from Jed Fahey at Johns Hopkins University. In an Instagram post (link) Rhonda mentions studies have shown that many cocoa products have high levels of cadmium and lead71Cadmium and lead in cocoa powder and chocolate products in the US Market Abt et al (2017). This could lead to increased cardiovascular risk as a result58Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease van den Heuvel et al. Her response in her May 2022 Q&A was that Athletic Greens contains a blue green micro algae called spirulina, which is a potential source of a liver toxin called microcistins. If she misses a dose in the morning then she will typically double up in the evening. Consuming this in addition to her regular omega-3 supplementation. Mentioning that higher levels are associated with a lower risk of all-cause mortality54Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies Harris et al. WebSulforaphane supplements have received attention from Dr. Rhonda Patrick and Tim Ferriss. Moringa is derived from the leaves of the Drumstick Tree, which are harvested, dried and then powdered. Choline is an essential micronutrient that plays crucial roles in: Rhonda aims to get the majority of choline from her diet. Its a sulfur-rich compound frequently found in cruciferous vegetables like broccoli, bok choy, and cabbage. At one stage she was taking Visbiome probiotics every few weeks, to top up her healthy gut bacteria. See here for the differences. Just passing along Rhonda Patrick information. ZMA supplements contain zinc and magnesium aspartate and B6. Clinical strength, requires refrigeration. Most recently Rhonda is taking a supplement called called, Previously she had supplemented it individually, via, Improvements to skin (decreased wrinkles and increased skin elasticity), Dark chocolate (85% cocoa), but not milk chocolate (35% cocoa), improved walking ability in elderly patients with peripheral artery disease, Increased endurance performance in young male cyclists who consumed dark chocolate showing a performance increase of 17% vs consuming white chocolate, Cocoa consumption decreased blood pressure in healthy individuals, in a dose dependent manner, Increased cognition in young adults, measured via a cognitively demanding test, Protection from cognitive decline in the elderly, Adding moringa powder to room temperature water at ratio of 1:100 powder to water, Leaving to stand for at least 10 minutes prior to drinking. Specifically their Cardio Health version, which she takes in the morning due to it containing a small amount of caffeine (for 15% off, you can use this coupon code). The supplement she uses, Pure Encapsulations Calcium K/D, has 200 mg of calcium per pill, which is what she takes daily. She didnt mention the frequency, whether its daily or every few days. WebDr. In part, this is because fish dont actually produce omega-3s, instead they get them from the plankton and algae in their diet so by consuming algae youre going direct to the source49Omega-3: A Link between Global Climate Change and Human Health Jing X. Kang | 2011 | Biotechnology Advances. Unfortunately this particular product she uses, Norwegian PURE-3, has had inventory issues for some time and is unavailable for order. She mentioned this specifically on Joe Rogan podcast #1474, and then more recently in her July 2022 Q&A. Dr. Rhonda Patrick's recent interview of Dr. David Sinclair about the NMN supplement shelf life (nicotinamide mononucleotide, an NAD+ precursor) has created quite a stir among NMN users. Firstly, this crowd sponsored support allows her to continue to work independently, without being reliant on sponsors or grants. Rhonda Patricks top pick Rhondas current probiotic comes from Visbiome. Its available in powder and capsule form, with Rhonda preferring the powder with 450 billion live bacteria per packet. This product arrives with a cold pack to maintain its potency. Dosage Rhondas Method for Choosing Supplement Brands, Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg), Calcium Intake From Diet and Supplements and the Risk of Coronary Artery Calcification and its Progression Among Older Adults: 10Year Followup of the MultiEthnic Study of Atherosclerosis (MESA), Omega-3: A Link between Global Climate Change and Human Health, Metabolism of -linolenic acid in humans, Blood docosahexaenoic acid and eicosapentaenoic acid in vegans: Associations with age and gender and effects of an algal-derived omega-3 fatty acid supplement, Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies, The Omega-3 Index: Clinical Utility for Therapeutic Intervention, Vitamin D: A Micronutrient Regulating Genes, Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES, Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease, The relationship between vitamin K and peripheral arterial disease, Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration, Lutein and Zeaxanthin Supplementation and Association With Visual Function in Age-Related Macular Degeneration, Dietary guidance for lutein: consideration for intake recommendations is scientifically supported, Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake, Increased Bioavailability of Ubiquinol Compared to Ubiquinone, Dark Chocolate Acutely Improves Walking Autonomy in Patients With Peripheral Artery Disease, Dark chocolate supplementation reduces the oxygen cost of moderate intensity cycling, Cocoa consumption dose-dependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals, The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people, Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study, Cocoa Flavanol Supplementation Influences Skin Conditions of Photo-Aged Women: A 24-Week Double-Blind, Randomized, Controlled Trial, Cadmium and lead in cocoa powder and chocolate products in the US Market, Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Studya randomized controlled trial, Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Intake of other supplements did not have an effect on sperm or sex hormones. **Heavy metals will never be zero, but "Passed" in this context means that it passed the IFOS tests and is low enough to not be of concern. See this and this Instagram post for more on Rhonda discussing salmon roe. This transport system appears to continue to work even when regular DHA transport is impaired. The specific product she notes using is called Thorne Citramate. Dr. Rhonda Patrick takes 3 grams a day. How much fish oil does Dr. Rhonda Patrick take daily? Dr. Rhonda Patrick takes 3 grams a day. To be honest, this supplement tends to be a little higher in price range. But the more you read about the benefits, you see why Dr. Rhonda Patrick supplements with it. She also questions the value of metformin in healthy individuals who exercise. Webdr rhonda patrick vitamin d joe rogan. Rhonda opts for the sachets which contain 4x as many live bacteria. Vitamin K is an essential micronutrient, thats plays a crucial role in the ability to form blood clots, and to transport calcium around the body. Luteolin is a type of flavonoid found in small quantities in fruits and vegetables. Please note that where I link to products, some of these links are affiliate links. abductor digiti minimi pain foot; vicksburg high school football schedule 2022; elbow clicking tricep extension; why are my messages green and not sending; Medicare Supplement She expressed her concern at lead chromate being added to turmeric during processing to enhance the yellow color. Its been linked to digestive and heart health benefits. Then separately see this post on the supplements Rhonda gave to her growing toddler. It is noticeably expensive, even for ubiquinol. Therefore its important to use blood testing to ensure youre staying within the healthy range. Examples of stand-alone vitamin D supplements include: Rhonda currently supplements vitamin K on the basis that its an insurance policy, in case she doesnt get enough K from vegetables. Thats a blow for dark chocolate fans (myself included) who hadnt considered heavy metal consumption might be a risk. She adjusts her supplements over time, and this post is kept continually updated. Probiotics. The reason for this is that phospholipid DHA gets converted to DHA-lysoPC, by a specialized transporter called MFSD2A85Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid Nguyen et al (2014). Additionally a double-blind, randomized and placebo-controlled trial showed antidepressive effects in patients with major depression, Produce the neurotransmitter acetylcholine, important for memory, mood, muscle control, and other brain and nervous system functions, Important roles in modulating gene expression, cell membrane signaling, lipid transport and metabolism, and early brain development, Regular cardio exercise such as running/spin bike, Intermittent fasting such that she stays in ketosis throughout the morning while she works, Consuming sulforaphane which raises glutathione in the brain, lowering oxidative stress + inflammation, High dose fish oil of which the DHA is key for brain function, A 50/50 split between coconut powder and MCT powder, The cocoa powder naturally contains a small amount of caffeine, so she avoids drinking the mix too late in the day, as that can impact sleep. Rhondas current hypothesis for why is that at lower doses resveratrol may act as a mild antioxidant, which then blunts the positive effects of exercise (similar to high dose Vitamin E). Additionally, an 18% increase in the content of haemoglobin was found in the skin dermis suggesting improved microcirculation (study source). She currently uses a blend of vitamin D3, vitamin K1 and calcium. When that task is satisfied, then the level of K1 increases in the blood, and helps to transport calcium for use around the body. David supplements with ~1 gram of powdered resveratrol every morning, mixed in with some yogurt (once again, brand not disclosed) Why yogurt? WebSummary. Thorne contains magnesium, copper, calcium and gamma tocopherol, whilst ONE does not. Dr. Rhonda Patrick. Additionally, Rhondas interest was piqued by a study showing that in 26 healthy females who displayed visible signs of natural and photoaging in the face, daily supplementation with 1 gram of collagen powder for 12 weeks led to a 76% reduction of skin dryness/scaling and a 13% decrease in global lines and wrinkles. Find Dr. Harmon's phone number, address, hospital affiliations and more. Ie she takes one each day for a month, then switches to the other one for a month. Probiotics: VSL#3 Sachets. Suboptimal magnesium status in the United States: are the health consequences underestimated? However, it suggests that higher intakes are safe, for example with a human intervention study using 20 mg / day of Zeaxanthin, for 6 months, showing no adverse affects. In Jeds studies on Moringa, participants consumed it as a cold-brewed tea. In recent years its become popular amongst biohackers looking to extend their healthspan + lifespan. (2014). Rhonda Patrick Supplements - What Does She Take? Rhonda cites 3 potential benefits of cocoa flavanols: See the studies Rhonda mentions in regard to enhanced circulation: Then studies in regards to enhanced cognition: Then lastly, a Korean study showed 320mg of cocoa daily reduced wrinkles and increased skin elasticity (measured after 24 weeks)70Cocoa Flavanol Supplementation Influences Skin Conditions of Photo-Aged Women: A 24-Week Double-Blind, Randomized, Controlled Trial Chung et al. Below well look at supplements Rhonda used during her pregnancy (a section which, of course, wont be applicable to all). Rhonda notes in her recent Joe Rogan interview (#1701) shes a proponent of whats called the omega-3 index test. ApoE4 increases Alzheimers risk between 2-3x if youve 1 allele and 15x with 2 alleles. Its perhaps worth noting that CocoaVia also have a product called Memory+ (in a blue bottle). Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms, Luteolin suppresses inflammation-associated gene expression by blocking NF-B and AP-1 activation pathway in mouse alveolar macrophages, Luteolin Promotes Cell Apoptosis by Inducing Autophagy in Hepatocellular Carcinoma, Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects, Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ) on Cognitive Functions, Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled Study, Pure Encapsulations Phosphatidylcholine, Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases, Probiotics: progress toward novel therapies for intestinal diseases, P884 No shared mechanisms among old and new VSL#3: Implications for claims and guidelines, Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid, Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults, Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimers disease, Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men, Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women, Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin, Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, doubleblind, placebocontrolled, multicenter trial: The MASTERS trial, Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults, Andrew Huberman Supplements Full List Deep Dive Into What & Why, Rhonda Patrick Supplements List Updated February 2023, Peter Attia Supplements List What He Takes & Why, David Sinclair Supplements List Deep Dive into What & Why (2023), Andrew Huberman Diet and Routine What He Eats & Why.
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